Mouse models of Kcnq2 dysfunction.

Abstract excerpt

Variants in the Kv7.2 channel subunit encoded by the KCNQ2 gene cause epileptic disorders ranging from a benign form with self-limited epileptic seizures and normal development to severe forms with intractable epileptic seizures and encephalopathy. The biological mechanisms involved in these neurological diseases are still unclear. The disease remains intractable in patients affected by the severe form. Over the...

Topics

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• Brain Diseases
• Disease Models, Animal
• KCNQ2 Potassium Channel
• Mice
• Mutation
• Nerve Tissue Proteins