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Article

Postnatal Changes in K+/Cl- Cotransporter-2 Expression in the Forebrain of Mice Bearing a Mutant Nicotinic Subunit Linked to Sleep-Related Epilepsy.

Neuroscience - 21 Aug 2018

Amadeo Alida, Coatti Aurora, Aracri Patrizia, Ascagni Miriam, Iannantuoni Davide, Modena Debora, Carraresi Laura, Brusco Simone, Meneghini Simone, Arcangeli Annarosa, Pasini Maria Enrica, Becchetti Andrea

Abstract excerpt

The Na+/K+/Cl- cotransporter-1 (NKCC1) and the K+/Cl- cotransporter-2 (KCC2) set the transmembrane Cl- gradient in the brain, and are implicated in epileptogenesis. We studied the postnatal distribution of NKCC1 and KCC2 in wild-type (WT) mice, and in a mouse model of sleep-related epilepsy, carrying the mutant β2-V287L subunit of the nicotinic acetylcholine receptor (nAChR). In WT neocortex, immunohistochemistry...

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Identifiers

PMID: 29949744
DOI: 10.1016/j.neuroscience.2018.06.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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