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Overriding Mendelian inheritance in <i>Arabidopsis</i> with a CRISPR toxin-antidote gene drive that impairs pollen germination

2023-10-11

Abstract excerpt

Synthetic gene drives, inspired by natural selfish genetic elements, present transformative potential for disseminating traits that benefit humans throughout wild populations, irrespective of potential fitness costs. Here, we constructed a gene drive system called CRISPR-Assisted Inheritance utilizing NPG1 ( CAIN ), which employs a toxin-antidote mechanism in the male germline to override Mendelian inheritance i...

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Identifiers and source

Literature Corpus work
9c70c521-25d9-5d7d-9738-b3f16d46225e
DOI
10.1101/2023.10.10.561637
Open publication

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Overriding Mendelian inheritance in <i>Arabidopsis</i> with a CRISPR toxin-antidote gene drive that impairs pollen germinationDOI 10.1101/2023.10.10.561637
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