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Article

A toxin-antidote CRISPR gene drive system for regional population modification.

Nature communications - 27 Feb 2020

Champer Jackson, Lee Esther, Yang Emily, Liu Chen, Clark Andrew G, Messer Philipp W

Abstract excerpt

Engineered gene drives based on a homing mechanism could rapidly spread genetic alterations through a population. However, such drives face a major obstacle in the form of resistance against the drive. In addition, they are expected to be highly invasive. Here, we introduce the Toxin-Antidote Recessive Embryo (TARE) drive. It functions by disrupting a target gene, forming recessive lethal alleles, while rescuing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32109227
DOI: 10.1038/s41467-020-14960-3
PMCID: PMC7046741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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