Article

Massively parallel phenotyping of variant impact in cancer with Perturb-seq reveals a shift in the spectrum of cell states induced by somatic mutations

2020-11-17

Abstract excerpt

Genome sequencing studies have identified millions of somatic variants in cancer, but their phenotypic impact remains challenging to predict. Current experimental approaches to distinguish between functionally impactful and neutral variants require customized phenotypic assays that often report on average effects, and are not easily scaled. Here, we develop a generalizable, high-dimensional, and scalable approach...

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Literature Corpus work: 94a4f8ec-251a-509d-ab49-8583c1964c12
DOI: 10.1101/2020.11.16.383307

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