Article

Repurposing niclosamide as a novel anti-SARS-Cov-2 drug by restricting entry protein CD147

2023-04-13

Abstract excerpt

<h4>Background: </h4> The burst of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the global COVID-19 pandemic. But until today only limited numbers of drugs are discovered to treat COVID-19 patients. Even worse, the rapid mutations of SARS-CoV-2 compromise the effectiveness of existing vaccines and neutralizing antibodies due to the increased viral transmissibility and immune escape. CD14...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e44bb83-373b-5d9a-8d6e-5ddb1926e1c0
DOI: 10.21203/rs.3.rs-2763207/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repurposing niclosamide as a novel anti-SARS-Cov-2 drug by restricting entry protein CD147DOI 10.21203/rs.3.rs-2763207/v1Read

A vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of COVID-19 and related diseasesSemantic proximity Read

In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 TreatmentSemantic proximity Read

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variantsSemantic proximity Read

Meplazumab treats COVID-19 pneumonia: an open-labelled, concurrent controlled add-on clinical trialSemantic proximity Read

Niclosamide reverses SARS-CoV-2 control of lipophagySemantic proximity Read

Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variantSemantic proximity Read

In silico analysis suggests the RNAi-enhancing antibiotic enoxacin as a potential inhibitor of SARS-CoV-2 infectionSemantic proximity Read

HuR enhances SARS-CoV-2 non-structural protein translation through the genomic 5’-UTR, by promoting polypyrimidine tract-binding protein bindingSemantic proximity Read

Niclosamide Prodrug Enhances Oral Bioavailability and Efficacy Against Hepatocellular Carcinoma by Targeting Vasorin-TGFβ SignalingSemantic proximity Read

Niclosamide Prodrug Enhances Oral Bioavailability and Targets Vasorin-TGFβ Signaling in Hepatocellular CarcinomaSemantic proximity Read

Development of a Novel Human CD147 Knock-in NSG Mouse Model to Test SARS-CoV-2 Viral InfectionSemantic proximity Read

Niclosamide Prodrug Enhances Oral Bioavailability and Targets Vasorin-TGFβ Signaling in Hepatocellular CarcinomaSemantic proximity Read