Article

CAF-1 in Replication and Repair: A Critical Genetic Mediator of Synthesis-Coupled Nucleosome Assembly

2026-07-28

Abstract excerpt

Eukaryotic genomes are organized into chromatin, a highly compact structure in which DNA is packaged into nucleosomes. Nucleosome formation, where DNA is wrapped around histone proteins, is essential for genome stability. This compaction protects DNA from damage and regulates accessibility of genes. Nucleosomes must be disassembled and reassembled during DNA replication and repair. These processes require precise...

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Literature Corpus work: 784fc72e-82b1-5b49-a4ac-65a2e4888ba1
DOI: 10.20944/preprints202607.1963.v1

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