Article

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

2020-01-05

Abstract excerpt

The coordinated transcription of genes involves the regulated release of RNA polymerase II (RNAPII) from promoter-proximal sites into active elongation. DNA lesions in transcribed strands block elongation and induce a strong transcriptional arrest. The transcription-coupled repair (TCR) pathway efficiently removes transcription-blocking DNA lesions, but this is not sufficient to resume transcription. Through prote...

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Literature Corpus work: a7bfe283-54e4-5706-b9c4-8f7bb0bc4304
DOI: 10.1101/2020.01.04.894808

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