Article

Endogenous mutational mechanisms and metabolic context shape endometrial cancer

2026-04-07

Abstract excerpt

Uterine corpus endometrial carcinoma (UCEC) is a common gynecologic malignancy with rising mortality, yet its genome-wide mutational architecture remains incompletely understood. Here we analyze deep whole-genome sequencing data from 440 UCEC tumors from The Cancer Genome Atlas, integrated with transcriptomic and clinical data, to define subtype-specific mutational processes and genomic architectures. We uncover p...

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Literature Corpus work: f22464a2-3b4a-5f6e-be3d-e0056881fdd1
DOI: 10.64898/2026.04.03.716356

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