Sparse polygenic risk score inference with the spike-and-slab LASSO.

Abstract excerpt

MOTIVATION: Large-scale biobanks, with rich phenotypic and genomic data across hundreds of thousands of samples, provide ample opportunities to elucidate the genetics of complex traits and diseases. Consequently, there is growing demand for robust and scalable methods for disease risk prediction from genotype data. Inference in this setting is challenging due to the high-dimensionality of genomic data, especially...

Topics

• Multifactorial Inheritance
• Humans
• Genome-Wide Association Study
• Algorithms
• Genetic Predisposition to Disease
• Bayes Theorem