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Article

Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction.

BMC bioinformatics - 9 Feb 2024

Zhuang Yongwen, Kim Na Yeon, Fritsche Lars G, Mukherjee Bhramar, Lee Seunggeun

Abstract excerpt

BACKGROUND: Genetic variants can contribute differently to trait heritability by their functional categories, and recent studies have shown that incorporating functional annotation can improve the predictive performance of polygenic risk scores (PRSs). In addition, when only a small proportion of variants are causal variants, PRS methods that employ a Bayesian framework with shrinkage can account for such...

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PMID: 38336614
DOI: 10.1186/s12859-024-05664-2
PMCID: PMC11323637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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