Article

Ageing-related defects in macrophage function are driven by <i>MYC</i> and <i>USF1</i> transcriptional programmes

2023-09-22

Abstract excerpt

<h4>Summary</h4> Macrophages are central innate immune cells whose function declines with age. The molecular mechanisms underlying age-related immunity changes remain poorly understood, particularly in human macrophages. We report a substantial reduction in phagocytosis, migration and chemotaxis in human monocyte-derived macrophages (MDMs) from older (>50 years) compared with younger (18-30 years) donors, alongsi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bb42f75-5e26-5ced-a9fe-0e26ed37ccbb
DOI: 10.1101/2023.09.20.558643

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ageing-related defects in macrophage function are driven by <i>MYC</i> and <i>USF1</i> transcriptional programmesDOI 10.1101/2023.09.20.558643Read

Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programsSemantic proximity Read

An integrated analysis of myeloid cells identifies gaps in <i>in vitro</i> models of <i>in vivo</i> biologySemantic proximity Read

Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleenSemantic proximity Read

Age-Related Alterations in Macrophage Distribution and Function Are Associated With Delayed Cutaneous Wound HealingSemantic proximity Read

Macrophages: development and tissue specialization.Semantic proximity Read

Single cell RNA sequencing reveals mechanisms underlying a senescence-like phenotype of Alveolar Macrophages during AgingSemantic proximity Read

Cellular reprogramming of human monocytes is regulated by time-dependent IL4 signalling and NCOR2Semantic proximity Read

MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis.Semantic proximity Read

Single-cell atlas reveals age-related cellular shifts underlying fibrosis in murine synoviumSemantic proximity Read

Lung environment in healthy old age shapes the phenotype and CCR2-mediated recruitment of a subset of apoptotic, high-turnover alveolar macrophagesSemantic proximity Read

Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin.Semantic proximity Read

Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice.Semantic proximity Read