Article

Single-cell atlas reveals age-related cellular shifts underlying fibrosis in murine synovium

2026-04-21

Abstract excerpt

Aging is a major risk factor for joint disease, yet the impact of physiological aging on the synovium remains poorly defined. Here we generate a single-cell atlas of murine ankle synovium across age and identify the sublining stromal-myeloid niche as a major site of age-associated remodeling. Aging shifted fibroblast states toward oxidative stress and matrix-remodeling programs, accompanied by sublining collagen a...

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Literature Corpus work: d2d20832-cdd6-5f15-a7c6-a6573988e4c3
DOI: 10.64898/2026.04.17.719179

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