Macrophages: development and tissue specialization.

doi:10.1146/annurev-immunol-032414-112220

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Article

Macrophages: development and tissue specialization.

Annual review of immunology - 1 Jan 2015

Varol Chen, Mildner Alexander, Jung Steffen

Abstract excerpt

Macrophages are myeloid immune cells that are strategically positioned throughout the body tissues, where they ingest and degrade dead cells, debris, and foreign material and orchestrate inflammatory processes. Here we review two major recent paradigm shifts in our understanding of tissue macrophage biology. The first is the realization that most tissue-resident macrophages are established prenatally and...

Topics

Animals
Cell Differentiation
Humans
Immunity
Macrophages
Organ Specificity
Phenotype

Source

Open in PubMed

Identifiers

PMID: 25861979
DOI: 10.1146/annurev-immunol-032414-112220

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