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Article

Macrophages Are Polarized toward an Inflammatory Phenotype by their Aged Microenvironment in the Human Skin.

The Journal of investigative dermatology - 1 Dec 2022

Gather Leonie, Nath Neetika, Falckenhayn Cassandra, Oterino-Sogo Sergio, Bosch Thomas, Wenck Horst, Winnefeld Marc, Grönniger Elke, Simm Stefan, Siracusa Annette

Abstract excerpt

Aging of the skin is accompanied by cellular as well as tissue environmental changes, ultimately reducing the ability of the tissue to regenerate and adequately respond to external stressors. Macrophages are important gatekeepers of tissue homeostasis, and it has been reported that their number and phenotype change during aging in a site-specific manner. How aging affects human skin macrophages and what...

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Identifiers

PMID: 35850208
DOI: 10.1016/j.jid.2022.06.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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