Article

Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen

2026-04-06

Abstract excerpt

<h4>ABSTRACT</h4> The spleen contains diverse macrophage subsets that remove aged erythrocytes, prevent the dissemination of circulating pathogens, and shape the adaptive immune response 1–3 . The mouse spleen hosts red pulp macrophages (RPM), marginal zone macrophages (MZM), marginal zone metallophilic macrophages (MMM), and tingible body macrophages (TBM). However, their transcriptomic identity, ontogeny, and...

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Literature Corpus work: 6c373fed-018e-5074-864b-f794c115f6eb
DOI: 10.64898/2026.04.02.716095

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