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Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs

1 Apr 2024

Abstract excerpt

Macrophages are central innate immune cells whose function declines with age. The molecular mechanisms underlying age-related changes remain poorly understood, particularly in human macrophages. We report a substantial reduction in phagocytosis, migration, and chemotaxis in human monocyte-derived macrophages (MDMs) from older (>50 years old) compared with younger (18-30 years old) donors, alongside downregulation...

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PMID: 38578825
DOI: 10.1016/j.celrep.2024.114073

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