Article

SAH and C. elegans Longevity: Insights from an AHCY Deficiency Model

2023-04-26

Abstract excerpt

<title>Abstract</title> <p>Supplementation with S-adenosylhomocysteine (SAH) extends the lifespan of model organisms. To explore the impact of SAH on aging, we generated a Caenorhabditis elegans model with increased SAH levels through pathogenic mutation in the S-adenosylhomocysteine hydrolase (AHCY), which impairs SAH hydrolysis to adenosine and homocysteine. We showed that animals with an endogenous mutation le...

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Literature Corpus work: 9b9f6657-a70b-5716-931f-65e6f802de86
DOI: 10.21203/rs.3.rs-2855835/v1

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