Article

Pharmacologic AMPK Activation Extends Lifespan in <i>C. elegans</i> and Improves Aspects of Healthspan in Mice

2026-04-23

Abstract excerpt

Dysregulated energy metabolism is a hallmark of aging. Many interventions that extend lifespan converge on the conserved master regulator of energy metabolism, AMP-activated kinase (AMPK), and direct genetic activation of AMPK extends lifespan in multiple species. Here, we test the ability of a specific and potent pharmacologic AMPK activator, MK-8722, to extend lifespan in C. elegans and improve healthspan in ag...

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Literature Corpus work: 07bc7854-2e68-5a99-b676-9820cce81b7f
DOI: 10.64898/2026.04.21.719899

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