Article

The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging

2023-07-19

Abstract excerpt

The renin-angiotensin-aldosterone system (RAAS) plays a well-characterized role regulating blood pressure in mammals. Pharmacological and genetic manipulation of the RAAS has been shown to extend lifespan in C. elegans , Drosophila , and rodents, but its mechanism is not well defined. Here we investigate the angiotensin-converting enzyme (ACE) inhibitor drug captopril, which extends lifespan in worms and mice. T...

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Literature Corpus work: 61146da9-35c9-5fe7-9225-c432113f5aae
DOI: 10.1101/2023.07.17.549402

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