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A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response.

Aging cell - 1 Dec 2018

Shamalnasab Mehrnaz, Gravel Simon-Pierre, St-Pierre Julie, Breton Lionel, Jäger Sibylle, Aguilaniu Hugo

Abstract excerpt

Plant extracts containing salicylates are probably the most ancient remedies to reduce fever and ease aches of all kind. Recently, it has been shown that salicylates activate adenosine monophosphate-activated kinase (AMPK), which is now considered as a promising target to slow down aging and prevent age-related diseases in humans. Beneficial effects of AMPK activation on lifespan have been discovered in the model...

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Source

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Identifiers

PMID: 30192051
DOI: 10.1111/acel.12830
PMCID: PMC6260907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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