Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

S-adenosyl methionine synthetase SAMS-5 mediates dietary restriction-induced longevity in Caenorhabditis elegans.

PloS one - 1 Jan 2020

Chen Chia-Chang, Lim Chiao Yin, Lee Pin-Jung, Hsu Ao-Lin, Ching Tsui-Ting

Abstract excerpt

S-adenosyl methionine synthetase (SAMS) catalyzes the biosynthesis of S-adenosyl methionine (SAM), which serves as a universal methyl group donor for numerous biochemical reactions. Previous studies have clearly demonstrated that SAMS-1, a C. elegans homolog of mammalian SAMS, is critical for dietary restriction (DR)-induced longevity in Caenorhabditis elegans. In addition to SAMS-1, three other SAMS paralogs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caloric Restriction

Share to Gene Expression Regulation

Share to Longevity

Share to Methionine Adenosyltransferase

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33175851
DOI: 10.1371/journal.pone.0241455
PMCID: PMC7657561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

S-adenosyl methionine synthetase SAMS-5 mediates dietary restriction-induced longevity in Caenorhabditis elegans.PMID 33175851Read ↗

Metformin induces S‐adenosylmethionine restriction to extend the Caenorhabditis elegans healthspan through H3K4me3 modifiersSemantic proximity Read ↗

SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevitySemantic proximity Read ↗

Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress SurvivalSemantic proximity Read ↗

Contribution of sams-1 and pmt-1 to lipid homoeostasis in adult Caenorhabditis elegans.Semantic proximity Read ↗

Glycine promotes longevity in <i>Caenorhabditis elegans</i> in a methionine cycle-dependent fashionSemantic proximity Read ↗

Optimizing Dietary Restriction for Genetic Epistasis Analysis and Gene Discovery in C. elegansSemantic proximity Read ↗

Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.Semantic proximity Read ↗

Mutation of C. elegans demethylase spr-5 extends transgenerational longevity.Semantic proximity Read ↗

SAH and C. elegans Longevity: Insights from an AHCY Deficiency ModelSemantic proximity Read ↗

Dietary methionine functions in proliferative zone maintenance and egg production via sams-1 in Caenorhabditis elegans.Semantic proximity Read ↗

Longevity determined by developmental arrest genes in Caenorhabditis elegans.Semantic proximity Read ↗

Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.