Article

Accumulation of S-adenosyl-L-homocysteine impairs methylation and development in Saccharomyces cerevisiae and Drosophila melanogaster

2024-09-24

Abstract excerpt

<title>Abstract</title> <p><italic>S</italic>-adenosyl-<italic>L</italic>-homocysteine (SAH), the product inhibitor of <italic>S</italic>-adenosyl-<italic>L</italic>-methionine (SAM)-dependent methyltransferases, and its degradation product homocysteine (Hcy) are evolutionarily conserved master regulators of methylation metabolism. They can affect more than 200 methyltransferases in humans interfering with numero...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4b517cf-d055-5beb-bd4a-dddc29ceace8
DOI: 10.21203/rs.3.rs-5144569/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Accumulation of S-adenosyl-L-homocysteine impairs methylation and development in Saccharomyces cerevisiae and Drosophila melanogasterDOI 10.21203/rs.3.rs-5144569/v1Read

S-adenosylhomocysteine hydrolase regulates anterior patterning in <i>Dugesia japonica</i>Semantic proximity Read

Homocysteine regulates fatty acid and lipid metabolism in yeast.Semantic proximity Read

S-adenosylhomocysteine Hydrolase Participates in DNA Methylation Inheritance.Semantic proximity Read

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability.Semantic proximity Read

Dysregulation of Epigenetic Mechanisms of Gene Expression in the Pathologies of HyperhomocysteinemiaSemantic proximity Read

A Metabolic Function for Phospholipid and Histone Methylation.Semantic proximity Read

SAH and C. elegans Longevity: Insights from an AHCY Deficiency ModelSemantic proximity Read

Inherited disorders in the conversion of methionine to homocysteineSemantic proximity Read

The Link Between Hyperhomocysteinemia and HypomethylationSemantic proximity Read

Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae.Semantic proximity Read

A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in Arabidopsis S-adenosylhomocysteine hydrolase.Semantic proximity Read

Homocysteine Thiolactone Detoxifying Enzymes and Alzheimer’s DiseaseSemantic proximity Read