Article

Cytoglobin regulates nitric oxide-dependent cilia motility and organ laterality in development

2022-10-11

Abstract excerpt

<title>Abstract</title> <p>Cytoglobin is a highly conserved redox sensor heme protein with unknown physiological function. Unexpectedly, genetic deletion of zebrafish cytoglobin (<italic>cygb2</italic>) causes cardiac and gastro-intestinal tract laterality defects, modeling Kartagener’s syndrome, which in humans is associated with low airway epithelial nitric oxide (NO) production. Cygb2 co-localized with cilia a...

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Literature Corpus work: 995edf4c-7d8b-5ce3-9521-f69750d219ff
DOI: 10.21203/rs.3.rs-2132286/v1

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