Article

Cytoglobin-dependent NO-sGC-cGMP signaling regulates ventricular morphogenesis and diastolic function

2026-03-17

Abstract excerpt

<h4>Aims</h4> Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease characterized by ventricular hypoplasia and impaired cardiac function. Clinically, inhaled nitric oxide (NO) therapy is used to reduce pulmonary vascular resistance and improve cardiopulmonary stability in HLHS patients. However, whether NO signaling contributes to HLHS pathogenesis remains unknown. Cytoglobin (Cygb) is a he...

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Literature Corpus work: 241fc576-6c56-5f8f-afc1-4d1c794b65e8
DOI: 10.64898/2026.03.13.711730

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