Article

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure

2024-05-03

Abstract excerpt

During heart failure, gene and protein expression profiles undergo extensive compensatory and pathological remodeling. We previously observed that fast skeletal myosin binding protein-C (fMyBP-C) is upregulated in diseased mouse hearts. While fMyBP-C shares significant homology with its cardiac paralog, cardiac myosin binding protein-C (cMyBP-C), there are key differences that may affect cardiac function. However,...

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Literature Corpus work: 0462c561-1a5e-55f2-8edb-8119b45534d3
DOI: 10.1101/2024.04.30.591979

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