Article
Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A.
The Journal of clinical investigation - 1 May 2003
Holtwick Rita, van Eickels Martin, Skryabin Boris V, Baba Hideo A, Bubikat Alexander, Begrow Frank, Schneider Michael D, Garbers David L, Kuhn Michaela
Abstract excerpt
Cardiac hypertrophy is a common and often lethal complication of arterial hypertension. Atrial natriuretic peptide (ANP) has been postulated to exert local antihypertrophic effects in the heart. Thus, a loss of function of the ANP receptor guanylyl cyclase-A (GC-A) might contribute to the increased propensity to cardiac hypertrophy, although a causative role in vivo has not been definitively demonstrated. To test...
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