Article
Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
Circulation research - 13 Apr 2001
Meeson A P, Radford N, Shelton J M, Mammen P P, DiMaio J M, Hutcheson K, Kong Y, Elterman J, Williams R S, Garry D J
Abstract excerpt
Mice lacking myoglobin survive to adulthood and meet the circulatory demands of exercise and pregnancy without cardiac decompensation. In the present study, we show that many myoglobin-deficient embryos die in utero at midgestation with signs of cardiac failure. Fetal mice that survive to gestational day 12.5, however, suffer no subsequent excess mortality. Survival in the absence of myoglobin is associated with...
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