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Article

Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy

13 Jun 2016

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and is associated with a number of potential outcomes, including impaired diastolic function, heart failure, and sudden cardiac death. Various etiologies have been described for HCM, including pressure overload and mutations in sarcomeric and non-sarcomeric genes. However, the molecular pathogenesis of HCM remains incompletely...

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PMID: 27378925
DOI: 10.3389/fphar.2016.00162

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