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Article

Investigation of microglial diversity in a LRRK2 G2019S mouse model of Parkinson's disease.

Neurobiology of disease - 1 Jun 2024

Iovino L, VanderZwaag J, Kaur G, Khakpour M, Giusti V, Donadon M, Chiavegato A, Tenorio-Lopes L, Greggio E, Tremblay M E, Civiero L

Abstract excerpt

Microglia contribute to the outcomes of various pathological conditions including Parkinson's disease (PD). Microglia are heterogenous, with a variety of states recently identified in aging and neurodegenerative disease models. Here, we delved into the diversity of microglia in a preclinical PD model featuring the G2019S mutation in LRRK2, a known pathological mutation associated with PD. Specifically, we...

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Identifiers

PMID: 38527708
DOI: 10.1016/j.nbd.2024.106481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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