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Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson’s disease

2025-07-30

Abstract excerpt

Neuroinflammation is increasingly recognized as a central pathological mechanism in Parkinson’s disease (PD), a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and variety of motor and non-motor symptoms. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome and its adaptor protein ASC play a critical role in initiating and maintaining inflam...

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Literature Corpus work
b548eefa-cd65-55ab-a01c-9ce03d1ed6c7
DOI
10.1101/2025.07.25.666809
Open publication

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Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson’s diseaseDOI 10.1101/2025.07.25.666809
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