Back to search

Article

Ropinirole hydrochloride mitigates oxidative stress and neuroinflammation via the PI3K–mTOR pathway in TDP-43 hiPSC-derived microglial-like cells

2026-03-10

Abstract excerpt

<h4>Background</h4> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss accompanied by neuroinflammation, oxidative stress, and impaired proteostasis, with pathological aggregation of TDP-43 as its defining hallmark. Microglia are recognized as central contributors to ALS pathogenesis, yet the mechanisms underlying their intrinsic dysfunction in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2f16b389-9033-5aa3-950b-d3afd2250911
DOI
10.64898/2026.03.07.710283
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Ropinirole hydrochloride mitigates oxidative stress and neuroinflammation via the PI3K–mTOR pathway in TDP-43 hiPSC-derived microglial-like cellsDOI 10.64898/2026.03.07.710283
Multiomic profiling reveals aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microgliaSemantic proximity
LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease modelSemantic proximity
Aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia.Semantic proximity
An adapted stem cell-derived microglia protocol for the study of microgliopathies and other neurological disordersSemantic proximity
Integration of iPSC-derived microglia into human midbrain organoids enhances microglial maturation and inflammatory signalingSemantic proximity
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegenerationSemantic proximity
Cell-autonomous immune dysfunction driven by disrupted autophagy in <i>C9orf72</i> -ALS iPSC-derived microglia contributes to neurodegenerationSemantic proximity
Regulatory Role of DDX17 in Immune-Autophagy Pathways of Parkinson’s Disease Revealed by Single-Cell and Genetic AnalysesSemantic proximity
Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesisSemantic proximity
Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function.Semantic proximity
The Interferon-miR-146a-5p-Stat1/Nrf2 Pathway Mediates LRRK2-R1441G-induced M1 over M2 Microglia Activation.Semantic proximity
Ropinirole hydrochloride for amyotrophic lateral sclerosis: A single-center, randomized feasibility, double-blind, placebo-controlled trialSemantic proximity
Select a neighboring publication to make it the new centre.