Article

Functional Testing of Thousands of Osteoarthritis-Associated Variants for Regulatory Activity

2018-07-30

Abstract excerpt

To date, genome-wide association studies have implicated at least 35 loci in osteoarthritis, but due to linkage disequilibrium, we have yet to pinpoint the specific variants that underlie these associations, nor the mechanisms by which they contribute to disease risk. Here we functionally tested 1,605 single nucleotide variants associated with osteoarthritis for regulatory activity using a massively parallel repor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f5809966-20b0-5191-bdc9-6126bdb31be1
DOI: 10.1101/379727

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional Testing of Thousands of Osteoarthritis-Associated Variants for Regulatory ActivityDOI 10.1101/379727Read

Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genesSemantic proximity Read

The Genetics and Functional Genomics of Osteoarthritis.Semantic proximity Read

Osteoarthritis as an Enhanceropathy: Gene Regulation in Complex Musculoskeletal Disease.Semantic proximity Read

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations.Semantic proximity Read

Decoding the genomic basis of osteoarthritisSemantic proximity Read

Saturation mutagenesis of disease-associated regulatory elementsSemantic proximity Read

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.Semantic proximity Read

The genetic architecture of osteoarthritis: insights from UK BiobankSemantic proximity Read

Genetics of osteoarthritis.Semantic proximity Read

A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritisSemantic proximity Read

Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genes.Semantic proximity Read

3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genesSemantic proximity Read