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Article

Genetic alternative splicing regulation mapping of cartilage and synovium reveals tissue-specific mechanisms of joint-related traits.

Nature communications - 12 Mar 2026

Tian Wen, Hu Shou-Ye, Dong Shan-Shan, Wang Chen, Zhang Jun-Qi, Jiang Feng, Yang Zhi, Yang Tie-Lin, Guo Yan

Abstract excerpt

Cartilage and synovium are essential tissues involved in joint-related diseases and traits, including osteoarthritis (OA), rheumatoid arthritis (RA), and human height. Although genome-wide association studies (GWAS) identify numerous risk loci for these traits, the molecular mechanisms underlying these associations, particularly those involving alternative splicing, remain poorly understood due to the lack of...

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Identifiers

PMID: 41820402
DOI: 10.1038/s41467-026-70419-x
PMCID: PMC13121699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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