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USP7/Maged1-Mediated H2A Monoubiquitination in the Paraventricular Thalamus: An Epigenetic Mechanism Involved in Cocaine Use Disorder

2022-11-17

Abstract excerpt

The individual risk of developing drug addiction is highly determined by the epigenetic landscape 1,2 . Chromatin remodeling regulates drug-induced transcriptional and behavioral effects and the consequent development of addictive behaviors 2,3 . Several chromatin modifications in the ventral tegmental area and nucleus accumbens, including histone H3 methylation, H3 and H4 acetylation, have been implicated in dr...

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Literature Corpus work: 9b4fcae5-4ee9-5601-9972-796e27b23e9f
DOI: 10.1101/2022.11.16.516716

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