Article

Methamphetamine induced regional-specific transcriptomic and epigenetic changes in the rat brain

2022-06-17

Abstract excerpt

<h4>Background</h4> Methamphetamine (METH) is a highly addictive central nervous system stimulant. Chronic use of METH is associated with multiple neurological and psychiatric disorders. An overdose of METH can cause brain damage and even death. Mounting evidence indicates that epigenetic changes and functional impairment in the brain occur due to addictive drug exposures. However, the responses of different brai...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f98521b5-729c-5459-9f73-28556b09ef7f
DOI: 10.1101/2022.06.13.496004

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Methamphetamine induced regional-specific transcriptomic and epigenetic changes in the rat brainDOI 10.1101/2022.06.13.496004Read

Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use DisorderSemantic proximity Read

Hippocampal single-cell RNA Atlas of chronic methamphetamine abuse-induced cognitive decline in miceSemantic proximity Read

Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studiesSemantic proximity Read

Epigenetic Effects Induced by Methamphetamine and Methamphetamine‐Dependent Oxidative StressSemantic proximity Read

Sex-specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent BrainsSemantic proximity Read

The DNA methylation enzymatic machinery in substance use disorders: a systematic reviewSemantic proximity Read

Brain Transcriptome Analysis Reveals Exercise Improves Methamphetamine-Induced Impairments in Mouse Learning and Memory AbilitiesSemantic proximity Read

Persistent large-scale changes in alternative splicing in prefrontal cortical neuron types following psychedelic exposureSemantic proximity Read

Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric disease heritabilitySemantic proximity Read

Methamphetamine induces alterations in the long non-coding RNAs expression profile in the nucleus accumbens of the mouseSemantic proximity Read

Integrative transcriptomic analysis identifies long noncoding RNA dysregulation and circadian disruption in reward and executive circuits of opioid use disorderSemantic proximity Read

Expression quantitative trait locus rs6356 is associated with the susceptibility of heroin addiction by potentially influencing the TH gene expression in the hippocampus and nucleus accumbensSemantic proximity Read