Article

Epigenetic editing of Cartpt promotes acquisition and extinction of cocaine memory

2025-11-20

Abstract excerpt

<h4>ABSTRACT</h4> In classic disease models, removing a pathological insult restores homeostasis. Yet, addiction persists far beyond the period of active drug use. Cocaine abstinence induces changes in gene expression and neuronal signaling in reward-related brain regions that limit recovery during abstinence. We found that 2 weeks of abstinence increased Cartpt (cocaine- and amphetamine-regulated transcript) in...

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Literature Corpus work: e3278070-3c15-595b-b8ea-d674fdef57c7
DOI: 10.1101/2025.11.20.689329

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