Article

<i>Tmod2</i> is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticity

2019-05-30

Abstract excerpt

Drugs of abuse induce neuroadaptations, including synaptic plasticity, that are critical for transition to addiction, and genes and pathways that regulate these neuroadaptations are potential therapeutic targets. Tropomodulin 2 ( Tmod2 ) is an actin-regulating gene that plays an important role in synapse maturation and dendritic arborization and has been implicated in substance-abuse and intellectual disability...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d2e5de5d-9d26-530b-a87e-ae5cb86cb72c
DOI: 10.1101/648295

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Tmod2</i> is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticityDOI 10.1101/648295Read

D2 autoreceptors gate vulnerability to cocaine use disorderSemantic proximity Read

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.Semantic proximity Read

Cell type-specific Multi-Omics Analysis of Cocaine Use Disorder in the Human Caudate NucleusSemantic proximity Read

Cytoplasmic FMR1-interacting protein 2 regulates cocaine reward by modulating synaptic plasticity in the nucleus accumbensSemantic proximity Read

Molecular genetics of cocaine use disorders in humansSemantic proximity Read

The mutated cytoplasmic fragile X messenger ribonucleoprotein 1 (FMR1)-interacting protein 2 (CYFIP2 S968F) regulates cocaine-induced reward behaviour and plasticity in the nucleus accumbens.Semantic proximity Read

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.Semantic proximity Read

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction.Semantic proximity Read

Meso-limbic Gene Expression Findings from Mouse Cocaine Self-Administration Recapitulate Human Cocaine Use DisorderSemantic proximity Read

Transcriptional control of nucleus accumbens neuronal excitability by Retinoid X Receptor Alpha tunes sensitivity to drug rewardsSemantic proximity Read

A Molecular Profile of Cocaine Abuse Includes the Differential Expression of Genes that Regulate Transcription, Chromatin, and Dopamine Cell PhenotypeSemantic proximity Read

Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusersSemantic proximity Read