Article

SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress

2021-10-14

Abstract excerpt

Stress exposure is a cardinal risk factor for most psychiatric diseases. Preclinical and clinical studies point to changes in gene expression involving epigenetic modifications within mesocorticolimbic brain circuits. Brahma (BRM) and Brahma-Related-Gene-1 (BRG1) are ATPase subunits of the SWI/SNF complexes involved in chromatin remodeling, a process essential to enduring plastic changes in gene expression. Here,...

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Literature Corpus work: f881e99a-1da1-5b3d-b933-3bf19780cc25
DOI: 10.1101/2021.10.14.464260

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