Article

Cell type-specific Multi-Omics Analysis of Cocaine Use Disorder in the Human Caudate Nucleus

2024-08-15

Abstract excerpt

<title>Abstract</title> <p>Structural and functional alterations in the brain's reward circuitry are present in cocaine use disorder (CocUD), but their molecular underpinnings remain unclear. To investigate these mechanisms, we performed single-nuclei multiome profiling on postmortem caudate nucleus tissue from six individuals with CocUD and eight controls. We profiled 31,178 nuclei, identifying 13 cell types inc...

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Literature Corpus work: 1c7aef86-76c8-5b89-94b9-8c6104a50738
DOI: 10.21203/rs.3.rs-4834308/v1

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