Article

Domain-selective BET inhibition attenuates transcriptional and behavioral responses to cocaine

2021-10-05

Abstract excerpt

Epigenetic pharmacotherapies have emerged as a promising treatment option for substance use disorder (SUD) due to their ability to reverse maladaptive transcriptional and behavioral responses to drugs of abuse. In particular, inhibitors of bromodomain and extra terminal domain (BET) reader proteins have been shown to reduce cocaine- and opioid-seeking behaviors in rodents. However, only pan-BET inhibitors, small m...

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Literature Corpus work: e8275f56-aaef-5432-b70e-0df6ad5492a1
DOI: 10.1101/2021.10.04.463083

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