Article

Cell-Type-Specific Epigenetic Priming of Gene Expression in Nucleus Accumbens by Cocaine

2022-06-26

Abstract excerpt

<h4>ABSTRACT</h4> A hallmark of addiction is the ability of drugs of abuse to trigger relapse after periods of prolonged abstinence. Here, we describe a novel epigenetic mechanism whereby chronic cocaine exposure causes lasting chromatin and downstream transcriptional modifications in the nucleus accumbens (NAc), a critical brain region controlling motivation. We link prolonged withdrawal from cocaine to the depl...

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Literature Corpus work: 693228f2-f1cf-545b-a880-f1b00fd23ebe
DOI: 10.1101/2022.06.24.497533

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