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DNA Methylation Dynamics and Cocaine in the Brain: Progress and Prospects

12 May 2017

Abstract excerpt

Cytosine modifications, including DNA methylation, are stable epigenetic marks that may translate environmental change into transcriptional regulation. Research has begun to investigate DNA methylation dynamics in relation to cocaine use disorders. Specifically, DNA methylation machinery, including methyltransferases and binding proteins, are dysregulated in brain reward pathways after chronic cocaine exposure....

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PMID: 28498318
DOI: 10.3390/genes8050138

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