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Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time

16 Feb 2016

Abstract excerpt

Canonical signal transduction via heterotrimeric G proteins is spatially and temporally restricted, that is, triggered exclusively at the plasma membrane (PM), only by agonist activation of G protein-coupled receptors (GPCRs) via a process that completes within a few hundred milliseconds. Recently, a rapidly emerging paradigm has revealed a non-canonical pathway for activation of heterotrimeric G proteins by the...

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PMID: 26879989
DOI: 10.1002/bies.201500133

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