Article

Opposing roles of GSDMD and NINJ1 shape early IL-1β–dependent host defense during <i>Toxoplasma gondii infection</i>

2026-06-01

Abstract excerpt

Inflammasome activation is a central component of host defense against Toxoplasma gondii , yet how downstream pyroptotic effectors shape infection outcomes remains incompletely understood. Here, we show that infection of primary macrophages with virulent type I T. gondii induces time-dependent NLRP3 inflammasome activation, caspase-1 cleavage, IL-1β secretion, and cell death. Unexpectedly, although caspase-1/11...

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Literature Corpus work: 8bc8a864-dc16-5a66-bd1d-38007f41ce00
DOI: 10.64898/2026.05.28.728484

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