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Article

Paradoxical Roles of the MAL/Tirap Adaptor in Pathologies

25 Sept 2020

Abstract excerpt

Toll-like receptors (TLRs) are at the forefront of pathogen recognition ensuring host fitness and eliciting protective cellular and humoral responses. Signaling pathways downstream of TLRs are tightly regulated for preventing collateral damage and loss of tolerance toward commensals. To trigger effective intracellular signaling, these receptors require the involvement of adaptor proteins. Among these,...

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PMID: 33072109
DOI: 10.3389/fimmu.2020.569127

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