Toll-Like Receptors, Transduction-Effector Pathways, and Disease Diversity: Evidence of an Immunobiological Paradigm Explaining All Human Illness?

Abstract excerpt

Membrane-bound Toll-like receptors (TLRs) are frontline guardians in the mammalian innate immune system. They primarily function to recognize pathogen-associated molecular patterns (PAMPs) of invading microorganisms and on activation mount rapid, nonspecific innate responses and trigger sequential delayed specific adaptive cellular responses, which are mediated by complex signal transduction pathways involving...

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