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Article

Mal, more than a bridge to MyD88

24 Aug 2013

Abstract excerpt

The family of type 1 transmembrane proteins known as Toll-like receptors (TLRs) provide early immune system recognition and response to infection. In order to transmit their signal to the nucleus and initiate activation of pro-inflammatory and anti-microbial genes, TLRs must initiate a cytoplasmic signalling cascade, which is alternately controlled by 6 known signalling adaptors. These signaling adaptors are...

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PMID: 23983209
DOI: 10.1002/iub.1201

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