Article

BET protein inhibitor JQ1 reduces inflammation and hippocampal amyloid-β level without altering Tau phosphorylation in LPS-challenged adult wild-type mice

2025-09-22

Abstract excerpt

<h4>Introduction</h4> A growing body of evidence highlights the role of infection and inflammation in the progression of Alzheimer’s disease (AD). In this study, we aimed to analyze the impact of JQ1, an inhibitor of bromodomain and extraterminal domain (BET) proteins, which are key readers of the epigenetic acetylation code, on AD-related gene expression changes and biochemical alterations in the hippocampus dur...

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Literature Corpus work: 9b2d61a5-c30b-5064-881c-3bbd98641f21
DOI: 10.1101/2025.09.22.677813

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