Article
Small molecule cognitive enhancer reverses age-related memory decline in mice
2020-04-15
Abstract excerpt
<h4>ABSTRACT</h4> With increased life expectancy age-associated cognitive decline becomes a growing concern, even in the absence of recognizable neurodegenerative disease. The integrated stress response (ISR) is activated during aging and contributes to age-related brain phenotypes. We demonstrate that treatment with the drug-like small-molecule ISR inhibitor ISRIB reverses ISR activation in the brain, as indicat...
Topics
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- Alzheimer's disease research and treatments
- Endoplasmic Reticulum Stress and Disease
- GDF15 and Related Biomarkers
- Genomics, phytochemicals, and oxidative stress
- Heat shock proteins research
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
Identifiers and source
- Literature Corpus work
- 5a90aa3e-c9bc-57ef-b822-22bb004774fa
- DOI
- 10.1101/2020.04.13.039677